Combinatorial G-CSF/AMD3100 Treatment in Cardiac Repair after Myocardial Infarction
نویسندگان
چکیده
منابع مشابه
Combinatorial G-CSF/AMD3100 Treatment in Cardiac Repair after Myocardial Infarction
AIMS Several studies suggest that circulating bone marrow derived stem cells promote the regeneration of ischemic tissues. For hematopoietic stem cell transplantation combinatorial granulocyte-colony stimulating factor (G-CSF)/Plerixafor (AMD3100) administration was shown to enhance mobilization of bone marrow derived stem cells compared to G-CSF monotherapy. Here we tested the hypothesis wheth...
متن کاملExosomes and cardiac repair after myocardial infarction.
Myocardial infarction is a leading cause of death among all cardiovascular diseases. The analysis of molecular mechanisms by which the ischemic myocardium initiates repair and remodeling indicates that secreted soluble factors are key players in communication to local and distant tissues, such as bone marrow. Recently, actively secreted membrane vesicles, including exosomes, are being recognize...
متن کاملGrowth differentiation factor 5 regulates cardiac repair after myocardial infarction.
OBJECTIVES The aim of this study was to examine the function of the bone morphogenic protein growth differentiation factor 5 (Gdf5) in a mouse model of myocardial infarction (MI). BACKGROUND The Gdf5 has been implicated in skeletal development, but a potential role in the heart had not been studied. METHODS The Gdf5-knockout (KO) and wild-type (WT) mice were subjected to permanent left ante...
متن کاملThe Inflammatory Response and Cardiac Repair After Myocardial Infarction
One of the most important therapeutic targets of current cardiology practice is to determine optimal strategies for the minimization of myocardial necrosis and optimization of cardiac repair following an acute myocardial infarction. Myocardial necrosis after acute myocardial infarction induces complement activation and free radical generation, triggering a cytokine cascade initiated by tumor ne...
متن کاملInjectable Hydrogels for Cardiac Tissue Repair after Myocardial Infarction
Cardiac tissue damage due to myocardial infarction (MI) is one of the leading causes of mortality worldwide. The available treatments of MI include pharmaceutical therapy, medical device implants, and organ transplants, all of which have severe limitations including high invasiveness, scarcity of donor organs, thrombosis or stenosis of devices, immune rejection, and prolonged hospitalization ti...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2014
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0104644